2 Chronicles 36:16 But they mocked the messengers of God, and despised his words, and misused his prophets, until the wrath of the Lord arose against his people, till there was no remedy.
The kings and the people of God kept on sinning against the Commandments and worshipping false gods. Therefore, the curses of the Covenant must come into effect and the nation be destroyed. However, the Lord still had compassion on them and wanted them to turn to Him in repentance and be blessed and restored. So He sent messengers to call them to repent and return. However, they did not listen, and so the wrath of God came against them until there was no remedy.
But they mocked the messengers of God, despised His words, and misused His prophets. God came to them with His Word because He had compassion on them, but they rejected His warnings and ignored His love. We also need to listen to the Lord speaking to us, calling us to repent and return. If we respond to God’s words and messengers with indifference we do so at our own peril. We listen and respond to the Word.